- ￥880
- Bioss
- bs-11326P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11326P |
| 英文名称 | PCP4 Antibody Blocking Peptide |
| 中文名称 | 脑特异性多肽蛋白19封闭多肽 |
| 英文别名 | Brain specific antigen PCP 4; Brain specific polypeptide PEP 19; Brain specific polypeptide PEP19; PEP19; Purkinje cell protein 4; PCP-4; PCP4_HUMAN; PEP-19. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Soma marker Signal Transduction > Signaling Pathway > Calcium Signaling > Calmodulin Pathway |
| 亚基 | Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater. |
| 相似性 | Belongs to the PCP4 family. Contains 1 IQ domain. |
| 功能 | Probable regulator of calmodulin signaling. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | PCP-4 is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome. |
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PCP4 Antibody Blocking Peptide(bs-11326P)-500ug
￥880
