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- bs-11456P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11456P |
| 英文名称 | Dscam Antibody Blocking Peptide |
| 中文名称 | 唐氏综合征细胞粘附分子封闭多肽 |
| 英文别名 | CHD2 42; CHD2 52; CHD2; Down syndrome cell adhesion molecule; DSCAM; DSCAM_HUMAN; human CHD2-52 down syndrome cell adhesion molecule 2, 9; OTTHUMP00000109193 2; SD11109p. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins |
| 亚基 | Interacts with DCC; the interaction is abolished in response to NTN1 (By similarity). Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts (via extracellular domain) with NTN1. Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1. Interacts with RAC1; the interaction requires PAK1. |
| 亚细胞定位 | Secreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. |
| 组织特异性 | Primarily expressed in brain. |
| 翻译后修饰 | Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin. |
| 相似性 | Contains 6 fibronectin type-III domains. Contains 10 Ig-like C2-type (immunoglobulin-like) domains. |
| 功能 | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted. |
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Dscam Antibody Blocking Peptide(bs-11456P)-500ug
￥880
