- ￥880
- Bioss
- bs-13955P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13955P |
| 英文名称 | CILP2 Antibody Blocking Peptide |
| 中文名称 | 软骨中间层蛋白CILP2封闭多肽 |
| 英文别名 | Cartilage intermediate layer protein 2 C2; CILP-2; CILP2; CILP2_HUMAN; MGC45771. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Secreted > extracellular space > extracellular matrix. |
| 组织特异性 | Expressed in articular chondrocytes but not in knee meniscal cartilage cells. |
| 翻译后修饰 | May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. |
| 相似性 | Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TSP type-1 domain. |
| 功能 | May play a role in cartilage scaffolding. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cartilage intermediate layer protein (CILP), an extracellular matrix protein, shows abundant expression in cartilagenous tissues. CILP is expressed as two isoforms, CILP and CILP-2, which are differentially expressed by chondrocytes and induced by TGF∫1. This induction is mediated by Smad3 through direct interactions with cis-elements in the CILP promoter region. TGF∫ also induces elevated chondrocyte extracellular inorganic pyrophosphate (PPi), which promotes the deposition of calcium pyrophosphate dihydrate crystals. The CILP isoforms have been implicated in common musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis and lumbar disc disease. |
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CILP2 Antibody Blocking Peptide(bs-13955P)-500ug
￥880
