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| 产品编号 | bs-1073P |
| 英文名称 | NME2 Antibody Blocking Peptide |
| 中文名称 | 肿瘤抑制基因NME2封闭多肽 |
| 英文别名 | nucleoside dIPhosphatase kinase B; C myc purine binding transcription factor PUF; NDK B; NDKB; NDP kinase B; NDPKB; NM23 H2; NM23B; Nucleoside diphosphate kinase B; nm23-M2; NME2; Nucleoside diphosphate kinase alpha, p18-12d; puf; MGC107562; MGC107563; MGC111212; non-metastatic cells 2, protein (NM23B)expressed in; NDKB_HUMAN; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; nm23-H2. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism Neuroscience > Neurology process > Neurogenesis Signal Transduction > Metabolism > Energy Metabolism Signal Transduction > Second Messenger > Nucleotide Messenger > GTP |
| 亚基 | Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8. Interacts with AKAP13. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. |
| 组织特异性 | Ubiquitously expressed. |
| 相似性 | Belongs to the NDK family. |
| 功能 | Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NM23 is a heterodimeric protein functioning as a nucleoside diphosphate (NDP) kinase. NME1 and NME2 comprise the 152 amino acid A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and NM23 may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways. NEM2 has been identified as a putative tumor suppressor. High expression of mouse NME2 is detected in heart, liver, and kidney, with moderate expression in skeletal muscle, and negligible expression in other mouse tissues examined. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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