- ￥880
- Bioss
- bs-20009P
- 2025年10月16日
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500ug
| 产品编号 | bs-20009P |
| 英文名称 | ATP2B1 Antibody Blocking Peptide |
| 中文名称 | ATP酶钙离子转运蛋白PMCA3封闭多肽 |
| 英文别名 | ATP2B3; ATP2B3 protein; Calcium Pump PMCA3 ATPase; ATPase Ca++ transporting plasma membrane 3; Plasma membrane calcium ATPase 3; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium pump isoform 3; Plasma membrane calcium transporting ATPase 3; PMCA 3; PMCA3; PMCA3a; AT2B3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Metabolism > Plasma Membrane > ATPases Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues. |
| 相似性 | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. |
| 功能 | Calcium Pump PMCA3 ATPase belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. Calcium Pump PMCA3 ATPase is the plasma membrane calcium ATPase isoform 3. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from four distinct genes, PMCA1, 2, 3, and 4. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA3 expression is confined to brain and skeletal muscle. The PMCA4 gene is located on human chromosome 1q25 and is ubiquitously expressed. |
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ATP2B1 Antibody Blocking Peptide(bs-20009P)-500ug
￥880
