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- 2025年10月15日
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100ul
| 产品编号 | bs-13653R-APC |
| 英文名称 | Leupaxin Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的桩蛋白抗体 |
| 英文别名 | LDLP; LDPL; LPXN; LPXN_HUMAN. |
| 产品应用 | IF=1:50-200, ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Leupaxin |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Focal Adhesions |
| 亚细胞定位 | Cytoplasm |
| 功能 | Leupaxin is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Leupaxin is a 386 amino acid cytoplasmic protein and member of the paxillin family. Leupaxin is highly expressed in lymphoid tissues such as spleen, lymph node, thymus and appendix, with low expression in bone marrow and fetal liver. Consisting of four leucine-rich LD-motifs at the N-terminus and four LIM domains at the C-terminus, leupaxin associates with a member of the focal adhesion kinase family, PYK2, in lymphoid cells. The leupaxin and PYK2 complex is involved in cell type-specific signaling in which it regulates signaling at sites of adhesion. Leupaxin is a substrate for tyrosine kinase in lymphoid cells and is suggested to participate in and be regulated by tyrosine kinase activity. Leupaxin may be a potential progression marker for a subset of prostate cancer and may act as a novel coactivator of the androgen receptor. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:50-200} |
| {ICC/IF} | {1:100-500} |
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文献和实验Fluorochrome Absorption and Emission Spectra
light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes
Fluorochrome Absorption and Emission
for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes are useful in experiments
区、1个IgC样区、1个跨膜疏水区和1个由30个氨基酸组成的胞内区。不同于其他B7家族分子的是，它具有负向调节免疫应答的作用。PD-1和PD-L1是一对共抑制分子[3]。 这对共抑制分子，对癌细胞是如何发挥作用的呢。 憋急，听我慢慢道来！ 人类身体健康的卫士「T细胞」的活化是需要接收「双重信号」的：首先，T细胞表面受体（TCR）识别由抗原提呈细胞（APCs）提呈的抗原肽，使T细胞初步活化；然后，APC表面的共刺激分子与T细胞表面的相应共刺激分子结合，使T
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