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- bs-14583P
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| 产品编号 | bs-14583P |
| 英文名称 | EMILIN1 Antibody Blocking Peptide |
| 中文名称 | 弹性蛋白微原纤维界面因子1封闭多肽 |
| 英文别名 | Elastin microfibril interface located protein 1; Elastin microfibril interface located protein; Elastin microfibril interface-located protein 1; Elastin microfibril interfacer 1; EMIL1_HUMAN; EMILIN 1; EMILIN; EMILIN-1; Emilin1; gp115. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Angiogenesis > Growth Factors > TGF Cardiovascular > Blood > Blood Pressure regulation Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Other ECM Proteins |
| 亚基 | Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds. Interacts with EMILIN2. |
| 亚细胞定位 | Secreted; extracellular space; extracellular matrix. Found mainly at the interface between amorphous elastin and microfibrils. |
| 组织特异性 | Distributed in tissues where resilience and elastic recoil are prominent. Highest levels in the adult small intestine, aorta, lung, uterus, and appendix and in the fetal spleen, kidney, lung, and heart; intermediate expression was detected in adult liver, ovary, colon, stomach, lymph node and spleen; adult heart, bladder, prostate, adrenal gland, mammary gland, placenta and kidney showed low expression whereas a series of other adult tissues, including skeletal muscle and different regions of adult brain show no expression. |
| 相似性 | Contains 1 C1q domain. _x000D_ Contains 1 collagen-like domain. _x000D_ Contains 1 EMI domain. |
| 功能 | May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009] |
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文献和实验Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN- Secreting T Cells
, activate AEC buffer using H2 O2 (see Step 25). Anti-CD3 monoclonal antibody (mAb) (Fisher Scientific) Blocking buffer for ELISPOT assay CEF peptide pool (available from the NIH AIDS Research and Reagent Program and other commercial
0.3% hydrogen peroxide (prepare immediately before use) Blocking buffer (see recipe ) HCV‐specific primary antibody (Ab), e.g
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