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| 产品编号 | bs-16269P |
| 英文名称 | GPCR MRGE/GPCR GPR167 Antibody Blocking Peptide |
| 中文名称 | G蛋白偶联受体167封闭多肽 |
| 英文别名 | G protein coupled receptor 167; G-protein coupled receptor 167; GPR167; Mas related G protein coupled MRGE; MAS related GPR member E; Mas-related G-protein coupled receptor member E; MRGE; MRGPRE; MRGRE_HUMAN. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cell membrane. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Mas subfamily. |
| 功能 | Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MRGE is a 311 amino acid multi-pass membrane protein that acts as an orphan receptor and is though to influence nociceptor function. A member of the G-protein coupled receptor 1 family and MAS subfamily, MRGE is encoded by a gene that maps to human chromosome 11p15.4 and mouse chromosome 7 F5. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. |
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