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- 2025年10月16日
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| 产品编号 | bs-13348P |
| 英文名称 | GGT2 heavy chain Antibody Blocking Peptide |
| 中文名称 | γ-谷氨酰转肽酶2重链封闭多肽 |
| 英文别名 | GGT 2; GGT-2; Gamma-glutamyltranspeptidase 2 heavy chain; Gamma glutamyltranspeptidase 2; gamma-glutamyltranspeptidase; GGT2_HUMAN; Glutathione hydrolase 2; Gamma-glutamyltranspeptidase 2. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Membrane; Single-pass type II membrane protein. |
| 组织特异性 | Highly expressed in fetal and adult kidney and liver. |
| 相似性 | Belongs to the gamma-glutamyltransferase family. |
| 功能 | Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GGT acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage, and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts leukotriene C4 to leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and in human tissues, there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes. |
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