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500ug
| 产品编号 | bs-17271P |
| 英文名称 | SCARA5 Antibody Blocking Peptide |
| 中文名称 | 清道夫受体A亚型5封闭多肽 |
| 英文别名 | FLJ23907; MGC45780; NET33; SCAR5_HUMAN; SCARA 5; scara5; Scavenger receptor class A member 5; Scavenger receptor class A, member 5 (putative); Scavenger receptor class A, member 5; Scavenger receptor hlg; Tesr; Testis expressed scavenger receptor. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Vitamins / Minerals |
| 亚基 | Homotrimer. |
| 亚细胞定位 | Cell membrane. |
| 相似性 | Belongs to the SCARA5 family. _x000D_ Contains 1 collagen-like domain._x000D_ Contains 1 SRCR domain. |
| 功能 | Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SCARA5 is a 495 amino acid cell membrane protein. SCARA5 is expressed at high levels in testis, with highest levels specifically found in specific populations of epithelial cells and Sertoli cells. SCARA5 forms a homotrimer single-pass type II membrane complex present on the surface of the plasma membrane. Cells transfected with SCARA5 were able to bind particular gram-positive and gram-negative bacteria, suggesting a possible role for SCARA5 in immunity to infection. It has also been suggested that SCARA5 may be involved in transferrin delivery pathways. Expressed as four isoforms produced by alternative splicing, SCARA5 contains one collagen-like domain and one SRCR domain. |
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文献和实验Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN- Secreting T Cells
, activate AEC buffer using H2 O2 (see Step 25). Anti-CD3 monoclonal antibody (mAb) (Fisher Scientific) Blocking buffer for ELISPOT assay CEF peptide pool (available from the NIH AIDS Research and Reagent Program and other commercial
0.3% hydrogen peroxide (prepare immediately before use) Blocking buffer (see recipe ) HCV‐specific primary antibody (Ab), e.g
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