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- 2026年10月10日
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| 规格： | 20ug | 产品价格： | ￥680.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥2280.0 |
| 规格： | 500ug | 产品价格： | ￥6880.0 |
| 产品编号 | bs-41613P |
| 英文名称 | Recombinant human VEGF-165 protein, His (HEK293) |
| 中文名称 | 重组人血管内皮生长因子165蛋白 |
| 英文别名 | VEGF 165; Recombinant VEGF 165A; Vascuoar endothelial growth factor A; VEGF A; vascular endothelial growth factor A isoform 2 precursor; Vegf; VEGFA; MGC70609; MVCD1; VEGF; VPF; VEGFA_HUMAN; Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF; VEGF A Precursor. ;Recombinant human VEGF-165 protein, His (HEK293) |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 21 |
| 实际分子量 | 24kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | PBS (pH7.4). |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cancer > Growth factors > VEGF Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Cardiovascular > Angiogenesis > Growth Factors > VEGF > VEGF Developmental Biology > Organogenesis > Angiogenesis and vasculogenesis Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Co-factors Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Metabolism > Types of disease > Cancer Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Signal Transduction > Growth Factors/Hormones > VEGF |
| 亚基 | Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). |
| 亚细胞定位 | Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. |
| 组织特异性 | soform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. |
| 相似性 | Belongs to the PDGF/VEGF growth factor family. |
| 功能 | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). |
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文献和实验may become powerful tools in anti-cancer therapeutics. Lef1 contributes to the differentiation of bulge stem cells by nuclear translocation and cross-talk with the notch signaling pathway. 作者：Zhang Y, Yu J, Shi C, Huang Y, Wang Y, Yang T, Yang J. Lymphoid
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