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- bs-3855P
- 2025年10月16日
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500ug
| 产品编号 | bs-3855P |
| 英文名称 | HSD17B1 Antibody Blocking Peptide |
| 中文名称 | 羟类固醇脱氢酶17β-HSD封闭多肽 |
| 英文别名 | 11beta-HSD1; 17beta-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid dehydrogenasetype 1 EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; HSD17; Hydroxysteroid (17 beta) dehydrogenase 1; Placental 17 beta hydroxysteroid dehydrogenase. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Growth factors > Hormones Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism Metabolism > Types of disease > Cancer Neuroscience > Endocrine system > Gonadotrophic axis Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Metabolism > Energy Metabolism |
| 亚基 | Homodimer. |
| 亚细胞定位 | Cytoplasm. |
| 相似性 | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| 功能 | Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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