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- 规格：
500ug
| 产品编号 | bs-12060P |
| 英文名称 | Cyclin Y/Cyclin X Antibody Blocking Peptide |
| 中文名称 | 周期素Y/X封闭多肽 |
| 英文别名 | C10orf9; CBCP1; CCNX; CCNY; CFP1; Chromosome 10 open reading frame 9; Cyclin box carrying protein 1; Cyclin box protein 1; Cyclin fold protein 1; Cyclin X; Cyclin Y; CCNY_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cyclins > Other Cyclins Epigenetics and Nuclear Signaling > Cell cycle > Cyclins > Other Cyclins |
| 亚基 | Interacts with CDK14, CDK16 and LRP6. |
| 亚细胞定位 | Cell membrane; Lipid-anchor; Cytoplasmic side. Isoform 3: Nucleus |
| 组织特异性 | Widely expressed. |
| 翻译后修饰 | Ubiquitinated; leading to its degradation. |
| 相似性 | Belongs to the cyclin family. Cyclin Y subfamily. Contains 1 cyclin N-terminal domain. |
| 功能 | Cyclin Y is a cyclin which plays a role in the control of cell division cycles and regulation of cyclin dependent kinases (e.g., CDC2; MIM 116940). Single nucleotide polymorphism in Cyclin Y gene is associated with Crohn's disease and ulcerative colitis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cyclin Y is a 341 amino acid protein belonging to the cyclin family. Cyclin Y exists as three alternatively spliced isoforms and contains a cyclin N-terminal domain. Cyclin Y may control cell division cycles and regulate cyclin-dependent kinases.Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T, Y and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle, thereby regulating kinase activity. |
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文献和实验. Y., and Yao, S. Q. (2002) Antibody-based fluorescence detection of kinase activity on a peptide array. Bioorg.Med. Chem. Lett. 1 2 , 2085-2088. 7. Fukunaga, R. and Hunter, T. (1997) M N K 1 , a n e w M A P kinase-activated protein kinase
Synthesis and Probing of Membrane-bound Peptide Arrays
can be made. For the introduction of randomized X positions in the peptide sequences, take the appropriate Fmoc-AA-mix stock solution from the freezer, bring to room temperature, and activate by adding DIC (1.5 µl per 100 µl-vial
Staining Procedure for Flow Cytometric Detection of Human Cyclins
supernatant. 4. Resuspend pellet in Wash buffer to a final concentration of 1 x 107 cells/ml. 5. Aliquot 100 m l cell suspension (1 x 106 cells) into 12 x 75 mm tubes for staining. 6. Add 20 m l of anti-cyclin or isotype control antibody
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