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- 2025年10月16日
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500ug
| 产品编号 | bs-3830P |
| 英文名称 | AMBRA1 Antibody Blocking Peptide |
| 中文名称 | 自噬相关基因AMBRA1封闭多肽 |
| 英文别名 | Activating molecule in beclin 1 regulated autophagy; Activating molecule in BECN1 regulated autophagy protein 1; Hypothetical protein FLJ20294; Hypothetical protein LOC55626; KIAA1736; MGC33725; WDR94; AMRA1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Autophagy > Signal Transduction Cancer > Signal transduction > Autophagy Cardiovascular > Heart > Autophagy Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy Neuroscience > Neurology process > Neurogenesis |
| 亚基 | Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3. |
| 亚细胞定位 | Cytoplasmic vesicle, autophagosome. |
| 相似性 | Contains 3 WD repeats. |
| 功能 | Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | AMBRA1 regulates autophagy and development of the nervous system. It is a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. AMBRA1 is a positive regulator of the Becn1-dependent programme of autophagy, as revealed by its overexpression and by RNA interference experiments invitro. Notably, AMBRA1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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