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- bs-17265P
- 2026年10月10日
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500ug
| 产品编号 | bs-17265P |
| 英文名称 | SCAMP5 Antibody Blocking Peptide |
| 中文名称 | 分泌载体膜蛋白5封闭多肽 |
| 英文别名 | AI426171; AW558254; DKFZp686L1799; hSCAMP5; MGC24969; Sc5; SCAM5_HUMAN; Scamp5; Secretory carrier associated membrane protein 5; Secretory carrier membrane protein 5; Secretory carrier-associated membrane protein 5. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Secretory Vesicles Signal Transduction > Protein Trafficking > Organelle Proteins |
| 亚细胞定位 | Cell membrane. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Recycling endosome membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles. |
| 组织特异性 | Expressed both by neuronal and nonneuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculate of the cortex region (at protein level). |
| 相似性 | Belongs to the SCAMP family. SCAMP5 subfamily. |
| 功能 | Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN- Secreting T Cells
, activate AEC buffer using H2 O2 (see Step 25). Anti-CD3 monoclonal antibody (mAb) (Fisher Scientific) Blocking buffer for ELISPOT assay CEF peptide pool (available from the NIH AIDS Research and Reagent Program and other commercial
0.3% hydrogen peroxide (prepare immediately before use) Blocking buffer (see recipe ) HCV‐specific primary antibody (Ab), e.g
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