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- Bioss
- bs-13307P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-13307P |
| 英文名称 | GCAP2 Antibody Blocking Peptide |
| 中文名称 | 鸟苷酸环化酶激活蛋白2封闭多肽 |
| 英文别名 | GCAP 2; Guanylate Cyclase Activating Protein Photoreceptor 2; Guanylate Cyclase Activator 1B; Guanylin 2; Guanylyl cyclase-activating protein 2; GUC1B_HUMAN; GUCA 2; GUCA1B. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Sensory System > Visual system Signal Transduction > Signaling Pathway > Calcium Signaling |
| 亚细胞定位 | Cell membrane. Membranes of outer segment. |
| 组织特异性 | Retina. Cones and rod. |
| 相似性 | Contains 4 EF-hand domains. |
| 功能 | Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event. The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1. |
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GUCA1B | GCAP2 Ab Blocking Peptide(bs-13307P)-500ug
￥880
