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- bs-13306P
- 2025年10月16日
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500ug
| 产品编号 | bs-13306P |
| 英文名称 | GCAP1 Antibody Blocking Peptide |
| 中文名称 | 鸟苷酸环化酶激活蛋白1封闭多肽 |
| 英文别名 | COD3; GCAP 1; GCAP; Guanylate Cyclase Activating Protein Photoreceptor 1; Guanylate Cyclase Activating Protein Photoreceptor 1; Guanylate Cyclase Activator 1A; Guanylate Cyclase Activator 1A; Guanylin 1; Guanylin 1; guanylyl cyclase activating protein 1; Guanylyl cyclase-activating protein 1; GUC1A_HUMAN; GUCA; GUCA1; GUCA1A; GUCA1A. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Second Messenger > Nucleotide Messenger > cGMP |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments. |
| 相似性 | Contains 4 EF-hand domains. |
| 功能 | Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-The binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event. |
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GCAP1 Antibody Blocking Peptide(bs-13306P)-500ug
￥880
