- ￥880
- Bioss
- bs-13308P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-13308P |
| 英文名称 | GCAP3 Antibody Blocking Peptide |
| 中文名称 | 鸟苷酸环化酶激活蛋白3封闭多肽 |
| 英文别名 | GCAP 3; Guanylate cyclase activating photoreceptor 3; Guanylate cyclase activator 1C; Guanylyl cyclase activating protein 3; Guanylyl cyclase-activating protein 3; GUC1C_HUMAN; GUCA1C. |
| 纯化方法 | HPLC |
| 组织特异性 | Retina. |
| 相似性 | Contains 4 EF-hand domains. |
| 功能 | Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events. |
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GCAP3 Antibody Blocking Peptide(bs-13308P)-500ug
￥880
