GBA2 | NLGase Ab Blocking Peptide(bs-13297P)-500ug产品图

GBA2 | NLGase Ab Blocking Pept

ide(bs-13297P)-500ug
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  • bs-13297P
  • 2026年10月10日
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    • 规格:

      500ug

    产品编号bs-13297P
    英文名称GBA2 Antibody Blocking Peptide
    中文名称β葡萄糖苷酶2封闭多肽
    英文别名AD035; Beta glucocerebrosidase 2; Beta glucosidase 2; DKFZp762K054; glucosidase, beta (bile acid) 2; Glucosylceramidase 2; KIAA1605; MGC16895; Non lysosomal glucosylceramidase; GBA2_HUMAN.
    纯化方法HPLC
    研究领域

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism

    Signal Transduction > Metabolism > Energy Metabolism

    Signal Transduction > Metabolism > Lipid metabolism

    亚细胞定位Cell membrane; Single-pass membrane protein. Note=Not localized to lipid rafts.
    组织特异性Widely expressed. Highly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower level in liver.
    相似性Belongs to the non-lysosomal glucosylceramidase family. _x000D_
    功能GBA2 is a non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. It is involved in sphingomyelin generation and prevention of glycolipid accumulation. GBA2 may also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Beta-glucosidase 2, also known as non-lysosomal glucosylceramidase (NLGase), Glucosylceramidase 2, GBA2 or AD035, is a 927 amino acid non-lysosomal glucosylceramidase that catalyzes glucosylceramide into ceramide and free glucose, and is suggested to play a role in carbohydrate transport and metabolism. A single-pass membrane protein, Beta-glucosidase 2 exists as three alternatively spliced isoforms that are widely expressed but found at highest levels in placenta, kidney, brain, skeletal muscle, kidney and heart, with low levels found in liver. Beta-glucosidase 2 activity has been linked to sphingomyelin generation and prevention of glycolipid accumulation. The gene encoding Beta-glucosidase 2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.

     

     

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