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- bs-16188P
- 2025年10月16日
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500ug
| 产品编号 | bs-16188P |
| 英文名称 | FSTL3 Antibody Blocking Peptide |
| 中文名称 | FSTL3/FLRG蛋白封闭多肽 |
| 英文别名 | FLRG; follistatin-like 3; follistatin-like 3 glycoprotein; Follistatin-like protein 3; Follistatin-related gene protein; Follistatin-related protein 3; FSRP; Fstl3; FSTL3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Growth Factors/Hormones > Hormones Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage Stem Cells > Mesenchymal Stem Cells > Osteogenesis |
| 亚细胞定位 | Secreted and Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. |
| 组织特异性 | Expressed in a wide range of tissues. |
| 相似性 | Contains 2 follistatin-like domains. Contains 2 Kazal-like domains. Contains 1 TB (TGF-beta binding) domain. |
| 功能 | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FLRG (follistatin-related gene, follistatin-like-3 or FSTL3) is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differen-tiation factors and regulate their activity during development. The FSTL3 protein contains 2 potential N-glycosylation sites and the predicted mass of the unmodified core protein is 27 kDa. FLRG is expressed in a wide range of human and murine adult tissues and its expression seems to be tightly regulated during murine embryogenesis. Immunohistochemistry reveals the presence of FLRG in the basement membrane between the dermis and the epidermis and around blood vessels. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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