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- Bioss
- bs-13286P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-13286P |
| 英文名称 | RALGAPA1 Antibody Blocking Peptide |
| 中文名称 | Tuberin样蛋白1封闭多肽 |
| 英文别名 | DKFZp566D133; DKFZp667F074; GAP related interacting partner to E12; GARN L1; GARNL 1; GRIPE; GTPase activating Rap/RanGAP domain like 1; KIAA0884; Tuberin like protein 1; TULIP 1. TULIP1; RGPA1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity. Interacts with the HLH region of TCF3/isoform E12 (By similarity). |
| 亚细胞定位 | Cytoplasmic and Nuclear. Translocated to the nucleus when associated with TCF3/E12. |
| 组织特异性 | Widely expressed. |
| 相似性 | Contains 1 Rap-GAP domain. |
| 功能 | GTPase activating Rap/RanGAP domain-like 1 (GARNL1) is an interacting partner of the transcription factor TCF3/isoform E12, mainly in the developing embryonic forebrain. It may be an important transcriptional regulator of downstream target genes under the control of TCF3/E12, by disrupting HLH dimer formation of TCF3/E12 with other proteins and may be involved in neuronal differentiation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue. |
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RALGAPA1 | GARNL1 Ab Blocking Peptide(bs-13286P)-500ug
￥880
