- ￥880
- Bioss
- bs-3677P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-3677P |
| 英文名称 | PTGIS Antibody Blocking Peptide |
| 中文名称 | 前列环素合成酶封闭多肽 |
| 英文别名 | PTGI; PTGIS; CYP8; Cytochrome P450, family 8, subfamily A, polypeptide 1; EC 5.3.99.4; MGC126858; MGC126860; OTTHUMP00000031777; PGIS; Prostacyclin synthase; Prostaglandin I2 (prostacyclin) synthase; Prostaglandin I2 synthase; PTGIS_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Cardiovascular > Blood > Platelets Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cytochromes Cardiovascular > Vasculature > Vasodilation > Prostaglandins Developmental Biology > Reproduction > Placental development Immunology > Innate Immunity > Macrophage / Inflamm. Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases Metabolism > Pathways and Processes > Mitochondrial Metabolism > Cytochromes Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Signaling Pathway > Lipid Signaling > Prostaglandins |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass membrane protein. |
| 组织特异性 | Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate. |
| 相似性 | Belongs to the cytochrome P450 family. |
| 功能 | Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. |
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