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- bs-13261P
- 2025年10月16日
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500ug
| 产品编号 | bs-13261P |
| 英文名称 | GABPA Antibody Blocking Peptide |
| 中文名称 | GA结合蛋白转录因子α/GABP-α封闭多肽 |
| 英文别名 | E4TF 1A; E4TF1 60; E4TF1A; GA binding protein alpha chain; GA binding protein transcription factor alpha subunit 60kDa; GA binding protein transcription factor alpha subunit; GA-binding protein alpha chain; GABP A; GABP alpha subunit; GABP alpha subunit; GABP subunit alpha; Gabpa; GABPA_HUMAN; Human nuclear respiratory factor 2 subunit alpha; NFT 2; NFT2; NRF 2; NRF 2A; NRF2; NRF2A; Nuclear respiratory factor 2 alpha subunit; Nuclear respiratory factor 2 subunit alpha; Nuclear respiratory factor 2 subunit alpha; RCH04A07; Transcription factor E4TF1 60; Transcription factor E4TF1 60; Transcription factor E4TF1-60. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | Heterotetramer of two alpha and two beta subunits. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. |
| 功能 | Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-alpha and a GABP-alpha-associated subunit, GABP beta. GABP alpha binds to a specific DNA sequence and GABP beta exists as b1 and b2 splice variants that differ in their C-termini. In primary neuronal cultures, GABP beta is expressed in both the cytoplasm and the nucleus, whereas GABP alpha is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABP alpha beta heterodimer or a GABP alpha b heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo. The GABP alpha beta tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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