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- 2025年10月16日
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| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-33018P |
| 英文名称 | Recombinant human Thioredoxin, His |
| 中文名称 | 重组硫氧还蛋白 |
| 英文别名 | Thioredoxin; ADF; Surface associated sulphydryl protein; Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TXN protein; ADF; ATL derived factor; DKFZp686B1993; MGC61975; SASP; Surface associated sulphydryl protein; Surface-associated sulphydryl protein; TRDX; TRX 1; TRX; TRX1; TXN; TXN; ATL derived factor; ATL-derived factor; THIO_HUMAN; zgc:92903; Trx-Tag; Recombinant human Thioredoxin, His |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 12 |
| 实际分子量 | 12 kDa |
| 浓度 | ＞0.5 mg/ml |
| 研究领域 | Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress Signal Transduction > Protein Trafficking > ER Proteins |
| 亚基 | Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner. |
| 亚细胞定位 | Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. |
| 相似性 | Belongs to the thioredoxin family. Contains 1 thioredoxin domain. |
| 功能 | Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
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文献和实验[资源] 申请上传 Current Protocols In Protein Science （60M） 见公共邮箱
of Thioredoxin Fusion Proteins Chapter 7 Characterization of Recombinant Proteins Introduction Unit 7.1 Overview of the Characterization of Recombinant Proteins Unit 7.2 Determining the Identity and Purity of Recombinant Proteins by UV Absorption
Strategies to Optimize Protein Expression in E. coli
., and Manjunath, P. 2009b. Recombinant expression and affinity purification of a novel epididymal human sperm‐binding protein, BSPH1. Mol. Hum. Reprod. 15:105‐114. Leichert, L
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
Materials LB agar in Omni plates (see recipe ) with appropriate selection antibiotic Recombinant bacterial library
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