ESCO1 | EFO1 Ab Blocking Peptide(bs-14487P)-500ug产品图

ESCO1 | EFO1 Ab Blocking Pepti

de(bs-14487P)-500ug
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  • bs-14487P
  • 2026年10月10日
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    • 规格:

      500ug

    产品编号bs-14487P
    英文名称ESCO1 Antibody Blocking Peptide
    中文名称ECO1蛋白封闭多肽
    英文别名A930014I12Rik; CTF; CTF7 homolog 1; CTF7, S. cerevisiae, homolog of, 1; ECO1; ECO1 homolog 1; ECO1, S. cerevisiae, homolog of, 1; EFO1; EFO1p; ESCO1; ESCO1_HUMAN; ESO1; ESO1 homolog 1; ESO1, S. pombe, homolog of, 1; Establishment factor like protein 1; Establishment factor ortholog 1; Establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; Establishment of cohesion 1, S. cerevisiae, homolog of; establishment of sister chromatid cohesion N-acetyltransferase 1; hEFO1; HGNC:24645; KIAA1911; N acetyltransferase ESCO1;
    纯化方法HPLC
    研究领域

    Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Chromatid Cohesion

    亚细胞定位Nucleus. Chromosome. Nuclear at interphase, associated with chromosomes during mitosis.
    组织特异性Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
    翻译后修饰Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.
    相似性Belongs to the acetyltransferase family. GCN5 subfamily.
    功能Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.

     

     

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