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- bs-7673P
- 2025年10月16日
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500ug
| 产品编号 | bs-7673P |
| 英文名称 | PGLYRP1 Antibody Blocking Peptide |
| 中文名称 | 肽聚糖识别蛋白1封闭多肽 |
| 英文别名 | Peptidoglycan recognition protein 1; Peptidoglycan recognition protein; PGLYRP; PGLYRP1; PGRP; PGRP S; PGRP-PEN; PGRP-S; TAG7; TNFSF 3L; TNFSF3L; PGRP1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Receptors > Associated Proteins Cell Biology > Apoptosis > Receptors > Associated Proteins Immunology > Innate Immunity > Cytokines Microbiology > Protein > Human Protein > Defensin Neuroscience > Neurology process > Circadian Rhythm > Hormones |
| 亚基 | Homodimer; disulfide-linked. |
| 亚细胞定位 | Secreted. Cytoplasmic granule (Bysimilarity). |
| 组织特异性 | Highly expressed in bone marrow. Weakexpression found in kidney, liver, small intestine, spleen, thymus,peripheral leukocyte, lung, fetal spleen and neutrophils. |
| 翻译后修饰 | N-glycosylated. N-glycosylation is required for bactericidalactivity. |
| 相似性 | Belongs to the N-acetylmuramoyl-L-alanine amidase 2family. |
| 功能 | Pattern receptor that binds to murein peptidoglycans(PGN) of Gram-positive bacteria. Has bactericidal activity towardsGram-positive bacteria. May kill Gram-positive bacteria byinterfering with peptidoglycan biosynthesis. Binds also toGram-negative bacteria, and has bacteriostatic activity towardsGram-negative bacteria. Plays a role in innate immunity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRPS, PGRPIA, and PGRP-I-beta) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood. PGRPS is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. However, PGRPS may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50–100 times higher than in neutrophils. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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