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- Bioss
- bs-3626P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-3626P |
| 英文名称 | PRKCG Antibody Blocking Peptide |
| 中文名称 | 蛋白激酶C亚型G封闭多肽 |
| 英文别名 | PKC gamma; PKCC; PKC-gamma; PKCG; PRKCG; Protein kinase C gamma; Protein kinase C gamma polypeptide; Protein kinase C gamma type; SCA 14; SCA14. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with GRIA4. Interacts with CDCP1. Interacts with TP53INP1 and p53/TP53. |
| 亚细胞定位 | Cytoplasm.Cell membrane. |
| 组织特异性 | Expressed in Purkinje cells of the cerebellar cortex. |
| 翻译后修饰 | Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.Ubiquitinated. |
| 相似性 | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 C2 domain. Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 protein kinase domain. |
| 功能 | This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008] |
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PRKCG Antibody Blocking Peptide(bs-3626P)-500ug
￥880
