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- bs-11981P
- 2026年10月10日
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500ug
| 产品编号 | bs-11981P |
| 英文名称 | CACNA2D1 Antibody Blocking Peptide |
| 中文名称 | 钙通道L型α2多肽封闭多肽 |
| 英文别名 | Calcium channel L type DHPR alpha 2 subunit; CA2D1_HUMAN; CACN A2; CACNA2; CACNA2D1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; H_DJ0560O14.1; L type calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent calcium channel subunit alpha 2/delta 1; Voltage gated calcium channel subunit alpha 2/delta 1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; WUGSC:H_DJ0560O14.1. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Calcium Signaling > Calcium Channels > L-type Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels |
| 亚基 | Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein |
| 组织特异性 | Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. |
| 翻译后修饰 | Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked. |
| 相似性 | Belongs to the calcium channel subunit alpha-2/delta family. _x000D_ Contains 1 cache domain. _x000D_ Contains 1 VWFA domain. |
| 功能 | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-11981P is one synthetic peptide derived from human CACNA2/CACNA2D1. This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
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