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| 产品编号 | bs-11980P |
| 英文名称 | CABP4 Antibody Blocking Peptide |
| 中文名称 | 瞬时受体电位通道蛋白4封闭多肽 |
| 英文别名 | CABP 4; CaBP4; CABP4_HUMAN; Calcium binding protein 4; Calcium-binding protein 4; CSNB 2B; CSNB2B. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cytoplasm. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.Target information above from: UniProt accession P57796 The UniProt Consortium_x000D_ The Universal Protein Resource (UniProt) in 2010_x000D_ Nucleic Acids Res. 38:D142-D148 (2010). _x000D_ _x000D_ Information by UniProt |
| 组织特异性 | Expressed in retina and in the inner hair cells (IHC) of the cochlea. |
| 翻译后修饰 | Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity. |
| 相似性 | Contains 4 EF-hand domains. |
| 功能 | Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The calcium binding protein (CaBP) family shares much similarity to calmodulin. It has been shown that CaBP proteins can substitute functionally for, and probably augment the function of, calmodulin. Calcium binding proteins are a crucial part of calcium mediated cellular signal transduction in the central nervous system. There are several members of the family with varying expression patterns. CaBP1 and CaBP2 can be expressed as multiple, alternatively spliced variants in brain and retina. CaBP3, CaBP4 and CaBP 5 are restricted to retinal rod and cone cells. |
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文献和实验Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN- Secreting T Cells
, activate AEC buffer using H2 O2 (see Step 25). Anti-CD3 monoclonal antibody (mAb) (Fisher Scientific) Blocking buffer for ELISPOT assay CEF peptide pool (available from the NIH AIDS Research and Reagent Program and other commercial
0.3% hydrogen peroxide (prepare immediately before use) Blocking buffer (see recipe ) HCV‐specific primary antibody (Ab), e.g
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