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- bs-13249P
- 2025年10月16日
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500ug
| 产品编号 | bs-13249P |
| 英文名称 | GNAI1 Antibody Blocking Peptide |
| 中文名称 | G蛋白α抑制剂封闭多肽 |
| 英文别名 | G protein alpha inhibitor 1; Adenylate cyclase inhibiting G alpha protein; Adenylate cyclase inhibitory protein; Adenylate cyclase-inhibiting G alpha protein; G protein alpha inhibiting 1; G protein alpha inhibiting activity polypeptide 1; Gi; Gi inhibitory G protein; Gi1 protein alpha subunit; GNAI 1; GNAI1; GNAI1_HUMAN; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 1; Guanine nucleotide binding protein G(i) alpha 1 subunit; Guanine nucleotide-binding protein G(i) subunit alpha-1; OTTHUMP00000161319; OTTHUMP00000208047. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > Heterotrimeric G Proteins > G Proteins Signal Transduction > Signaling Pathway > G Protein Signaling > Heterotrimeric G Proteins > Regulators |
| 亚基 | Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. |
| 亚细胞定位 | Nucleus. Cytoplasm. Cell membrane. Cytoplasm > cytoskeleton > centrosome. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. |
| 相似性 | Belongs to the G-alpha family. G(i/o/t/z) subfamily. |
| 功能 | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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