- ￥3200
- Bioss
- IHC0690H
- 2025年10月15日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
50T
| 产品编号 | IHC0690H |
| 英文名称 | Human Cyclin B1 Ready-To-Use IHC Kit |
| 中文名称 | 人周期素B1即用型免疫组化试剂盒 |
| 英文别名 | Ccn-2; CCNB; CCNB1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb-4; Cycb-5; CycB1; Cycb1-rs1; I79_013589; CCNB1_HUMAN; G2 mitotic specific cyclin B1; G2/mitotic-specific cyclin-B |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚基 | Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187). |
| 亚细胞定位 | #Cytoplasm #Cytoskeleton #Nucleus |
| 翻译后修饰 | Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132). Deubiquitinated by USP22 during G2/M phase (PubMed:27030811). Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site. |
| 相似性 | Belongs to the cyclin family. Cyclin AB subfamily. |
| 功能 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Human breast cancer tissue slide using IHC0690H (Human Cyclin B1 Kit).
Immunohistochemical analysis of paraffin embedded Human esophagus tissue slide using IHC0690H (Human Cyclin B1 Kit).
Immunohistochemical analysis of paraffin embedded Human thymus tissue slide using IHC0690H (Human Cyclin B1 Kit).
Immunohistochemical analysis of paraffin embedded Human tonsil tissue slide using IHC0690H (Human Cyclin B1 Kit).
Immunohistochemical analysis of paraffin embedded Human colon cancer tissue slide using IHC0690H (Human Cyclin B1 Kit).
Immunohistochemical analysis of paraffin embedded Human brain tissue slide using IHC0690H (Human Cyclin B1 Kit).
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Human Cyclin B1 Ready-To-Use IHC Kit(IHC0690H)-50T
￥3200
