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- IHC0472H
- 2025年10月15日
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- 规格：
50T
| 产品编号 | IHC0472H |
| 英文名称 | Human NPHS2 Ready-To-Use IHC Kit |
| 中文名称 | 人肾小球裂孔膜蛋白PDCN即用型免疫组化试剂盒 |
| 英文别名 | AI790225; NPHS2; podocin; nephrosis 2; idiopathic; steroid resistant; NPHS2 gene; PDCN; Podocin; SRN1; PODO_HUMAN |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚基 | Interacts with nephrin/NPHS1 and KIRREL1. Interacts directly with CD2AP. Interacts with DDN (By similarity). |
| 亚细胞定位 | #Cell membrane #Endoplasmic reticulum #Membrane |
| 组织特异性 | Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli. |
| 翻译后修饰 | Isoform 2 Glycosylated. |
| 相似性 | Belongs to the band 7/mec-2 family. |
| 功能 | Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0472H (Human NPHS2 IHC Kit).
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Human NPHS2 Ready-To-Use IHC Kit(IHC0472H)-50T
￥3200
