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- IHC0375H
- 2025年10月15日
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- 规格：
50T
| 产品编号 | IHC0375H |
| 英文名称 | Human OLIG2 Ready-To-Use IHC Kit |
| 中文名称 | 人少突胶质细胞转录因子2即用型免疫组化试剂盒 |
| 英文别名 | AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17; bHLHe19; oligodendrocyte transcription factor 2 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚基 | Interacts with NKX2-2. Interacts with ZNF488. |
| 亚细胞定位 | #Cytoplasm #Nucleus |
| 组织特异性 | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| 功能 | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded human glioma tissue slide using IHC0375H (Human OLIG2 Kit).
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Human OLIG2 Ready-To-Use IHC Kit(IHC0375H)-50T
￥3200
