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- IHC0231H
- 2025年10月15日
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50T
| 产品编号 | IHC0231H |
| 英文名称 | Human CD80 Ready-To-Use IHC Kit |
| 中文名称 | 人刺激分子B7-1蛋白即用型免疫组化试剂盒 |
| 英文别名 | B7; B7-1; B71; Cd28l; Cd80; Ly-53; Ly53; MIC17; TSA1; Activation B7-1 antigen; B lymphocyte activation antigen B7; B7-1 antigen; BB1; CD28 antigen ligand 1; CD28LG; CD28LG1; CD80 antigen (CD28 antigen ligand 1; B7-1 antigen); CD80 antigen; CD80 molecule; CD80_HUMAN; Costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚基 | Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement. (Microbial infection) Interacts with adenovirus subgroup B fiber proteins. (Microbial infection) Interacts with Orthopoxvirus OPG038/M2 protein, inhibiting the interaction with CTLA4/CD152. |
| 亚细胞定位 | Membrane |
| 组织特异性 | Expressed on activated B-cells, macrophages and dendritic cells. |
| 功能 | Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0231H (Human CD80 IHC Kit).
Immunohistochemical analysis of paraffin embedded human lymph nodes tissue slide using IHC0231H (Human CD80 IHC Kit).
Immunohistochemical analysis of paraffin embedded human spleen tissue slide using IHC0231H (Human CD80 IHC Kit).
Immunohistochemical analysis of paraffin embedded human thymus tissue slide using IHC0231H (Human CD80 IHC Kit).
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Human CD80 Ready-To-Use IHC Kit(IHC0231H)-50T
￥3200
