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- IHC0130H
- 2025年10月15日
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50T
| 产品编号 | IHC0130H |
| 英文名称 | Human Cytokeratin 8 Ready-To-Use IHC Kit |
| 中文名称 | 人细胞角蛋白8即用型免疫组化试剂盒 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 性状 | Liquid |
| 研究领域 |
Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class I > Cytokeratins |
| 亚基 | Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. |
| 亚细胞定位 | Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. |
| 组织特异性 | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. |
| 翻译后修饰 | Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. |
| 相似性 | Belongs to the intermediate filament family. |
| 功能 | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. |
| 应用 | 推荐稀释比例 |
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文献和实验used in accordance withmanufacturer recommendationsSignalStain?DAB Substrate Kit #8059:IHC analysis of paraffin-embedded human breastcarcinoma using Phospho-Stat3 (Tyr705) (D3A7) XP? Rabbit mAb #9145. Chromogenicdetection was performed using #8059 (left
免疫组化网络资源集锦!!自己选看啊!8D1. Immunohistochemistry Resource Group - Information and support for the field of immunohistochemistry. Images, resources, group reports, online database, applied IHC and molecular morphology, IHC references, and employment
(50 to 100 µl) and incubate for 45 min. The secondary antibody should be absorbed against human serum; if not add 1% human serum before use. Most reagents are used at 1:100 or 1:200 dilution. 7- Wash twice in TBS 0.05M pH7.5 + 0.01% Tween
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