- ￥697 - 1173
- Bioss
- D61658
- 2025年10月17日
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- 详细信息
- 技术资料
- 规格：
5mg/10mg
| 规格： | 5mg | 产品价格： | ￥697.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1173.0 |
| 产品编号 | D61658 |
| 英文名称 | Trans-Tranilast |
| 中文名称 | 反-曲尼司特 |
| 英文别名 | Tranilast trans- |
| 理论分子量 | 327.33 |
| 保存条件 | 2-8℃ |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | trans-Tranilast (trans-MK-341) is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis. Target: Angiotensin Receptor Tranilast has been approved in Japan and South Korea, since 1982, for the treatment of bronchial asthma, with indications for keloids and hypertrophic scar added in 1993. Tranilast is also used to treat asthma, autoimmune diseases, atopic and fibrotic pathologies, and can also inhibit angiogenesis. The antiproliferative properties of tranilast were found that tranilast elicited an inhibitory effect on fibroblast proliferation in vitro and also suppressed collagen production both in vitro and in vivo . Tranilast also reduced the release of chemical mediators from mast cells and suppressed hypersensitivity reactions. Three-week-old C57Bl/10 and mdx mice received tranilast (~300 mg/kg) in their food for 9 weeks, after which fibrosis was assessed through histological analyses, and functional properties of tibialis anterior muscles were assessed in situ and diaphragm muscle strips in vitro. Tranilast administration did not significantly alter the mass of any muscles in control or mdx mice, but it decreased fibrosis in the severely affected diaphragm muscle by 31% compared with untreated mdx mice (P< 0.05) |
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Trans-Tranilast(D61658)-5mg/10mg
￥697 - 1173
