- ￥3400 - 5440
- Bioss
- D61621
- 2025年10月17日
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- 规格：
5mg/10mg
| 规格： | 5mg | 产品价格： | ￥3400.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥5440.0 |
| 产品编号 | D61621 |
| 英文名称 | THS-044 |
| 英文别名 | N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine; N-Morpholino-2-nitro-4-(trifluoromethyl)aniline |
| 理论分子量 | 291.2265 |
| 保存条件 | -20℃ |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. Target: HIF2α Limited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein. |
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THS-044(D61621)-5mg/10mg
￥3400 - 5440
