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- D56157
- 2025年10月17日
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1mg/5mg
| 规格： | 1mg | 产品价格： | ￥233.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥592.0 |
| 产品编号 | D56157 |
| 英文名称 | (RS)-(Tetrazol-5-yl)glycine |
| 英文别名 | D,L-(tetrazol-5-yl)glycine; LY 285265 |
| 理论分子量 | 143.1041 |
| 保存条件 | Powder: -20℃ for 3 years | In solvent: -80℃ for 1 year |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1/GluN2A, respectively. |
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文献和实验Radioligand Binding Assays for the Glycine Site on N‐Methyl‐D‐Aspartate Receptors
. Ivanovic, A., Reilander, H., Laube, B. and Kuhse, J. 1998. Expression and initial characterization of a soluble glycine binding domain of the N‐methyl‐D‐aspartate receptor NR1 subunit. J. Biol. Chem. 273:19933
The NMDA subtypes of glutamatergic receptors (NMDARs) are unusual in that their activation requires the binding of both glutamate and a co-agonist glycine or d -serine. Whereas glycine was first suggested to play such a role, it was later
Methods for the Detection of D-Amino-Acid Oxidase
according to the method of Laemmli (6 ) on a polyacrylamide-gradient (8-16%) slab gel (Tefco, Tokyo) with the electrophoresis buffer (25 mM Tris, 192 mM glycine, and 0.1% SDS) at 20 mA for about 1.5 hr. Hog kidney D-amino-acid oxidase (10 ng, Sigma) and prestained protein
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