- ￥480 - 1480
- Bioss
- D51449
- 2025年10月17日
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- 详细信息
- 技术资料
- 规格：
2mg/10mg
| 规格： | 2mg | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1480.0 |
| 产品编号 | D51449 |
| 英文名称 | DMH-1 |
| 中文别名 | ALK1/ALK2/ALK3/ALK6抑制剂 |
| 性状 | Lyophilized |
| 理论分子量 | 380.44 |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DMH-1 is a second-generation small molecule BMP inhibitor based on dorsomorphin. DMH-1 effectively inhibits the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Treatment with DMH1 reduced lung metastasis and the tumors were less proliferative and more apoptotic. In the surrounding tumor microenvironment, treatment with DMH1 altered fibroblasts, lymphatic vessels and macrophages to be less tumor promoting. These results indicate that inhibition of BMP signaling may successfully target both the tumor and the surrounding microenvironment to reduce tumor burden and metastasis. |
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DMH-1(D51449)-2mg/10mg
￥480 - 1480
