- ￥480 - 1480
- Bioss
- D50871
- 2025年10月17日
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- 详细信息
- 技术资料
- 规格：
2mg/10mg
| 规格： | 2mg | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1480.0 |
| 产品编号 | D50871 |
| 英文名称 | (S)-crizotinib |
| 中文别名 | MTH1抑制剂 |
| 性状 | Lyophilized |
| 理论分子量 | 450.34 |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | (S)-Crizotinib is a novel potent, selective and cell permeable MTH1 inhibitor with an IC50 of ~72 nM. MTH1 is a nucleotide pool sanitizing enzyme. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition and induces an increase in DNA single-strand breaks in cancer cells. In vivo it can effectively suppress tumor growth in colon carcinoma xenograft model by once per day oral dosing. (R)-Crizotinib, which is (R)-enantiomer of the drug, is inactive against MTH1 in vitro. Loss-of-function of MTH1 impaired growth of KRAS tumor cells. (S)-Crizotinib is a useful chemical probe to further validate MTH1 as a promising novel class of anticancer target. |
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(S)-crizotinib(D50871)-2mg/10mg
￥480 - 1480
