- ￥580 - 1880
- Bioss
- D50841
- 2025年10月17日
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- 详细信息
- 技术资料
- 规格：
2mg/10mg
| 规格： | 2mg | 产品价格： | ￥580.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1880.0 |
| 产品编号 | D50841 |
| 英文名称 | PFI-3 |
| 中文别名 | SMARCA Bromodomains抑制剂 |
| 性状 | Lyophilized |
| 理论分子量 | 321.37 |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. It also inhibits SMARCA2, but has no interaction with the other sub-family branches including PB1(2-4) and a kinase panel of 36 kinases. It accelerates FRAP recovery in cells at a concentration of 1 μM. The SWI/SNF-related, Matrix-associated, Actin-dependent Regulator of Chromatin (SMARC) proteins integrate into complexes that remodel chromatin. The SMARC family A (SMARCA) members SMARCA2 (also known as BRM) and SMARCA4 (also known as BRG1) are helicases that contain structurally-related bromodomains for binding acetylated lysine residues on target proteins. PFI-3 is a very useful chemical probe to study the key chromatin remodeling and transcription control. |
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PFI-3(D50841)-2mg/10mg
￥580 - 1880
