- ￥380 - 1280
- Bioss
- D51115
- 2025年10月17日
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- 详细信息
- 技术资料
- 规格：
10mg/2mg
| 规格： | 10mg | 产品价格： | ￥1280.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥380.0 |
| 产品编号 | D51115 |
| 英文名称 | BLU-9931 |
| 英文别名 | blu9931; 2-Propenamide, N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]-; N-(2-{[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino}-3-methylphenyl)acrylamide; BLU-9931; 1538604-68-0; |
| 中文别名 | FGFR4抑制剂 |
| 性状 | Lyophilized |
| 理论分子量 | 509.38 |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | BLU-9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU-9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU-9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor. |
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BLU-9931(D51115)-10mg/2mg
￥380 - 1280
