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| 规格: | 20ug | 产品价格: | ¥980.0 |
|---|---|---|---|
| 规格: | 50ug | 产品价格: | ¥1880.0 |
| 规格: | 100ug | 产品价格: | ¥2680.0 |
| 产品编号 | bs-103902P |
| 英文名称 | Recombinant Human BRD2 Protein, N-His |
| 英文别名 | Really interesting new gene 3 protein; KIAA9001; O27.1.1; BRD2; RING3; Bromodomain-containing protein 2 |
| 性状 | Lyophilized |
| 纯化方法 | AC |
| 理论分子量 | 15.31 kDa |
| 储存液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > RING Finger E3 Ligase Epigenetics and Nuclear Signaling > Bromodomains Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies Epigenetics and Nuclear Signaling > Transcription > Bromodomain containing Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚基 | Homodimer. Interacts with E2F1 and with histone H4acetylated at 'Lys-13'. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 2 bromo domains. _x000D_ Contains 1 ET domain. |
| 功能 | May play a role in spermatogenesis or folliculogenesis. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010] |
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文献和实验Protein‐Protein Interactions Identified by Pull‐Down Experiments and Mass Spectrometry
) formulation. Proteomics 2:486‐498. Brymora, A., Cousin, M.A., Roufogalis, B.D., and Robinson, P.J. 2001a. Enhanced protein recovery and reproducibility from pull‐down assays
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
scale. Methods Mol. Biol. 375:57‐78. Li, Q.Z., Zhou, J., Wandstrat, A.E., Carr‐Johnson, F., Branch, V., Karp, D.R., Mohan, C., Wakeland, E.K., and Olsen, N.J. 2007. Protein
Characterization of CGRP Receptor Binding
Literature Cited Aiyar, N., Disa, J., Siemens, I.R., and Nambi, P. 1997. Differential effects of guanine nucleotides on [125I]‐hCGRP(8‐37) binding to porcine
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