- ￥980 - 2680
- Bioss
- bs-103776P
- 2025年10月15日
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20ug/50ug/100ug
| 规格： | 20ug | 产品价格： | ￥980.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥1880.0 |
| 规格： | 100ug | 产品价格： | ￥2680.0 |
| 产品编号 | bs-103776P |
| 英文名称 | Recombinant Human NKX2-2 Protein, N-His-SUMO |
| 英文别名 | Homeobox protein Nkx-2.2; NKX2-2; Homeobox protein NK-2 homolog B; NKX2B; NKX2.2 |
| 性状 | Lyophilized |
| 纯化方法 | AC |
| 理论分子量 | 19.24 kDa |
| 储存液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 亚基 | Interacts with OLIG2 (By similarity). |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. |
| 功能 | May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-2.1, Nkx-2.2 and Nkx-2.9. Specifically, the Nkx-2.2 protein is responsible for directing ventral neuronal patterning in response to graded Shh signaling. In the pancreas, Nkx-2.2 is expressed in a, b and pancreatic polypeptide (PP) cells, but not in d cells. Nkx-2.2 expression is required for differentiation of pancreatic b cells, which produce insulin. Homozygous null mutations of the Nkx-2.2 gene in mice lead to severe hyperglycemia and death shortly after birth, which suggests that Nkx-2.2 may be an important therapeutic target for pancreatic diseases, including diabetes and cancer. |
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bs-103776P
￥980 - 2680
