- ￥1280 - 4180
- Bioss
- bs-103218P
- 2025年10月15日
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20ug/50ug/100ug
| 规格： | 20ug | 产品价格： | ￥1280.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2580.0 |
| 规格： | 100ug | 产品价格： | ￥4180.0 |
| 产品编号 | bs-103218P |
| 英文名称 | Recombinant Human CD316/IGSF8 Protein, C-His |
| 英文别名 | EWI2; IGSF8; CD316; Glu-Trp-Ile EWI motif-containing protein 2; Keratinocytes-associated transmembrane protein 4; LIR-D1; Prostaglandin regulatory-like protein; CD81P3; EWI-2; KCT-4; CD81 partner 3; Immunoglobulin superfamily member 8; IgSF8; KCT4; PGRL |
| 性状 | Lyophilized |
| 纯化方法 | AC |
| 理论分子量 | 62.38 kDa |
| 储存液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 亚基 | Interacts directly with CD82 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1. Interacts with CD81/tetraspanin-28. |
| 亚细胞定位 | Cell membrane; Single-pass membrane protein. |
| 组织特异性 | Expressed in lymphocytes as well as in many tissues with higher expression in brain. Detected in all regions of the brain with weak expression in the pituitary. Expressed selectively by neurons but not by glial cells. |
| 相似性 | Contains 4 Ig-like C2-type (immunoglobulin-like) domains. |
| 功能 | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IGSF8 is a 65kDa single-pass membrane protein that may play a key role in many of the functions attributed to CD81 and CD9, like Hepatitis C infection and oocyte fertilization. It is also believed that this protein acts as a negative regulator of cell motility (e.g. T-cell mobility, prostate cancer cell migration) and is involved in the regulation of neurite outgrowth and maintenance of the neural network in the brain. |
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bs-103218P
￥1280 - 4180
