phospho-Dynamin 1 (Ser774) Rab
bit pAb, PerCP-Cy5.5 conjugated(bs-13039R-PerCP-Cy5.5)-100ul- ￥2980
- Bioss
- bs-13039R-PerCP-Cy5.5
- 2025年09月30日
- 产品信息以Bioss网站为准
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100ul
| 产品编号 | bs-13039R-PerCP-Cy5.5 |
| 英文名称 | phospho-Dynamin 1 (Ser774) Rabbit pAb, PerCP-Cy5.5 conjugated |
| 中文名称 | PerCP-Cy5.5标记的磷酸化酶动力蛋白1抗体 |
| 英文别名 | Dynamin 1(phospho S774); Dynamin 1(phospho Ser774); p-Dynamin 1(S774); p-Dynamin 1(Ser774); B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human Dynamin 1 around the phosphorylation site of Ser774 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚基 | Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). |
| 亚细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. |
| 相似性 | Belongs to the dynamin family. _x000D_ Contains 1 GED domain. _x000D_ Contains 1 PH domain._x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ |
| 功能 | Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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phospho-Dynamin 1 (Ser774) Rabbit pAb, PerCP-Cy5.5 conjugated(bs-13039R-PerCP-Cy5.5)-100ul
￥2980
