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- bs-10471R-PE-Cy7
- 2026年10月17日
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- 技术资料
- 规格：
100ul
| 产品编号 | bs-10471R-PE-Cy7 |
| 英文名称 | DYNC1I2 Rabbit pAb, PE-Cy7 conjugated |
| 中文名称 | PE-Cy7标记的胞浆动力蛋白中间链2抗体 |
| 英文别名 | Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; Dynein intermediate chain 2, cytosolic; DH IC-2; DC1I2_HUMAN; DNCI2; DNCIC2; Dynein cytoplasmic intermediate polypeptide 2. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DYNC1I2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Dynein Tags & Cell Markers > Subcellular Markers > Cytoskeleton > Microtubules |
| 亚基 | Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1. Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. |
| 翻译后修饰 | The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding. |
| 相似性 | Belongs to the dynein intermediate chain family._x000D_
Contains 7 WD repeats. |
| 功能 | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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DYNC1I2 | DHIC-2 Rabbit pAb, PE-Cy7 conj.(bs-10471R-PE-Cy7)-100ul
￥2980
