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100ul
| 产品编号 | bsm-43043M-APC |
| 英文名称 | IL7R/CD127 Mouse mAb, APC conjugated |
| 中文名称 | APC标记的白细胞介素-7受体a（CD127）单克隆抗体 |
| 英文别名 | IL-7Rα; IL-7Ra; Interleukin-7 receptor subunit alpha; CD 127; CD127; CD127 antigen; CDW127; IL 7R alpha; IL 7R; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL7RA; IL7Ralpha; Interleukin 7 receptor alpha chain; Interleukin 7 receptor; Interleukin 7 receptor isoform H5 6; IL7RA_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human IL-7R Alpha / CD127 protein |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Cytokines > Interleukins Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage |
| 亚基 | The IL7 receptor is an heterodimer of IL7R and IL2RG. The TSLP receptor is an heterodimer of CRLF2 and IL7R. |
| 亚细胞定位 | Secreted and Cell membrane. |
| 翻译后修饰 | N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 4 subfamily. _x000D_ Contains 1 fibronectin type-III domain. |
| 功能 | Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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文献和实验Fluorochrome Absorption and Emission Spectra
light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes
Fluorochrome Absorption and Emission
for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes are useful in experiments
Wnt/β-catenin信号通路在实验性大鼠肝癌形成过程中的作用
ten in 信号通路中的几个关键因子为研究对象， 探讨它们在正常鼠肝、不典型增生鼠肝和肿瘤肝脏中的表达，以期揭示Wnt/β-catenin信号转导通路与肝肿瘤发生的关系，为临床上肝癌的诊治提供新的线索。 1 材料和方法 1. 1 材料 兔抗β- caten in及抗APC 抗体购自武汉博士德生物技术公司。鼠抗cyclin D1 mAb以及PV6001两步法检测试剂盒购自北京中杉生物技术公司。总RNA 提取试剂盒(W6701)购自上海华舜生物工程有限公司。逆转录试剂
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