IRS1 (p-S312) Rabbit pAb, HRP conj.(bs-5396R-HRP)-100ul产品图

IRS1 (p-S312) Rabbit pAb, HRP

conj.(bs-5396R-HRP)-100ul
收藏
  • ￥2980
  • Bioss已认证
  • bs-5396R-HRP
  • 2026年10月17日
    avatar
    北京博奥森生物技术有限公司
    品牌商
    10 年钻石会员

  • 企业认证

    点击 QQ 联系

    • 相关产品推荐更多 >

    万千商家帮你免费找货

    0 人在求购买到急需产品

    相关阅读

    细胞污染识别与处理全攻略：5 种常见类型+关键误区Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图
    • 详细信息
    • 文献和实验
    • 技术资料
    • 规格：

      100ul

    产品编号bs-5396R-HRP
    英文名称phospho-IRS1 (Ser312) Rabbit pAb, HRP conjugated
    中文名称HRP标记的磷酸化胰岛素受体底物-1抗体
    英文别名IRS1(phospho S312); IRS-1(phospho-Ser312); p-IRS1; IRS1(phospho-Ser789); IRS1_HUMAN; Insulin receptor substrate 1; IRS-1; IRS 1;
    产品应用IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated Synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser312
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Signal transduction

    Cardiovascular > Atherosclerosis > Diabetes associated

    Metabolism > Types of disease > Cancer

    Metabolism > Types of disease > Diabetes

    Metabolism > Types of disease > Heart disease

    Metabolism > Types of disease > Obesity

    Neuroscience > Neurology process > Metabolism

    Signal Transduction > Adapters > Cytoplasmic

    Signal Transduction > Growth Factors/Hormones > Insulin / Insulin-like

    Tags & Cell Markers > Cell Type Markers > Tumor Associated

    亚基Interacts with UBTF and PIK3CA. Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1 and FER. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK.
    亚细胞定位IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli.
    组织特异性Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.
    翻译后修饰Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
    相似性Contains 1 IRS-type PTB domain.
    _x000D_ Contains 1 PH domain.
    功能May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

    风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。

    图标文献和实验
    相关实验

    • （共享）免疫单词缩写及翻译

      rabbit serum albumin 兔血清白蛋白 R-Sc Reed-Sternberg's cell 瑞-司氏细胞 Z/R Reinheit Zahl 光密度比值 SAV small agranular vesicle 无颗粒小泡 SBA soybean agglutinin 大豆凝集素 SC secretory component 分泌成份 SCV small clear vesicle 清亮小泡 SDS sodium

    图标技术资料

    暂无技术资料 索取技术资料

    同类产品报价

    产品名称
    产品价格
    公司名称
    报价日期
    IRS1 Rabbit pAb
    ￥1024
    攸碧艾（上海）生物技术有限公司
    2026年09月09日询价
    IRS1 Rabbit pAb
    ￥1150
    武汉爱博泰克生物科技有限公司
    2026年06月25日询价
    Anti-BS69/HRP
    ￥220
    上海信裕生物科技有限公司
    2025年07月10日询价
    Anti-BS69/HRP
    ￥220
    上海再康生物科技有限公司
    2025年11月21日询价
    FITC Rabbit pAb, Gold conj.(bs-0366R-Gold)-500ul/1ml
    ￥980
    北京博奥森生物技术有限公司
    2026年10月17日询价
    IRS1 (p-S312) Rabbit pAb, HRP conj.(bs-5396R-HRP)-100ul
    ￥2980