H3C1 | Histone H3 (ac-K23) Rabbit pAb, PerCP-Cy5.5 conj.(bs-3774R-PerCP-Cy5.5)-100ul产品图

H3C1 | Histone H3 (ac-K23) Rab

bit pAb, PerCP-Cy5.5 conj.(bs-3774R-PerCP-Cy5.5)-100ul
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  • ￥2980
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  • bs-3774R-PerCP-Cy5.5
  • 2026年10月17日
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    北京博奥森生物技术有限公司
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      100ul

    产品编号bs-3774R-PerCP-Cy5.5
    英文名称Histone H3 (Acetyl K23) Rabbit pAb, PerCP-Cy5.5 conjugated
    中文名称PerCP-Cy5.5标记的乙酰化组蛋白H3抗体
    英文别名Acetyl-Histone H3(Lys23); H3K23Ac; Acetyl-Histone H3(K23); Histone H3(Acetyl-Lys23); Histone H3(Acetyl Lys23); Histone H3(Acetyl-K23); H3 histone family member E pseudogene; H3 histone family, member A; H3/A; H31_HUMAN; H3F3; H3FA; Hist1h3a; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; histone 1, H3a; Histone cluster 1, H3a; Histone H3 3 pseudogene; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; H3.1; H3/d; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C7; H3C8; H3FD;
    产品应用Flow-Cyt=1μg/Test, IF=1:100-500, ICC/IF=1:50-200

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthesised acetylpeptide derived from human Histone H3 around the acetylation site of K23
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300.
    研究领域

    Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies

    Epigenetics and Nuclear Signaling > Histones > H3 > Methylated

    亚基The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with GCN5, whereby H3S10ph increases histone-protein interactions. Interacts with PDD1 and PDD3.
    亚细胞定位Nucleus. Chromosome. Note=Localizes to both the large, transcriptionally active, somatic macronucleus (MAC) and the small, transcriptionally inert, germ line micronucleus (MIC).
    组织特异性Expressed in testicular cells.Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
    翻译后修饰Phosphorylated to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5. H3S10ph is only found in the mitotically dividing MIC, but not in the amitotically dividing MAC. H3S10ph is correlated with chromosome condensation during mitotic or meiotic micronuclear divisions._x000D_
    Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K9acK14ac is the preferred acetylated form of newly synthesized H3. Acetylation occurs almost exclusively in the MAC._x000D_
    Methylated to form H3K4me. H3K4me is only found in the transcriptionally active MAC. Methylated to form H3K9me in developing MACs during conjugation, when genome-wide DNA elimination occurs. At this stage, H3K9me specifically occurs on DNA sequences being eliminated (IES), probably targeted by small scan RNAs (scnRNAs) bound to IES, and is required for efficient IES elimination. H3K9me is required for the interaction with the chromodomains of PDD1 and PDD3._x000D_
    The full-length protein H3S (slow migrating) is converted to H3F (fast migrating) by proteolytic removal of the first 6 residues. H3F is unique to MIC, and processing seems to occur regularly each generation at a specific point in the cell cycle.
    相似性Belongs to the histone H3 family.
    功能Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H3 is deposited into chromatin exclusively through a DNA replication-coupled pathway that can be associated with either DNA duplication or DNA repair synthesis during meiotic homologous recombination.
    保存条件Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.

     

    应用推荐稀释比例
    {Flow-Cyt}{1μg/Test}
    {IF}{1:100-500}
    {ICC/IF}{1:50-200}

     

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    图标文献和实验
    相关实验

    • 基于PCR技术的染色质沉淀分析

      that was an interspecific hybrid (H) between Mus musculus domesticus (D, paternal genome) and Mus spretus (S, maternal genome). The native chromatin was then immunoprecipitated with rabbit polyclonal antisera to acetylation at lysine 9 of H3 (H3K9Ac) and to dimethylation

    • 【求助】蛋白激酶C的信号通路

      +e/MNcTXL5n8RmjoNHFCGBSf86HgcNl/Q/zf9vuKyPEgIvCGIxBJ8hsOacwwIhARiAhEBA5UBGqNqjWbdW1mtUrdyV+jXk1IYEMn4YM6nZDCutWqZR00rFzudxJZrSqt4jQGeGGlUkryU5yQd5U0nklDZ5tWqlZMJVhFW83qOrc7ruczQEBdHsWhjLryr9ZrXmZDaSCw5F9t1K2/UvY8KjXK0f+qSqEA8vGfJC77lUpFoiAsldKmPBG+r

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